[摘要]目的：探讨斑秃患者血清25-羟维生素D3水平及卡泊三醇局部治疗的临床效果。方法：选取笔者医院收治的92例斑秃患者和60例健康志愿者，比较两组血清25-羟维生素D3水平。将斑秃患者中血清25-羟维生素D3水平正常和低下者分为正常组和低下组，斑秃患者中根据治疗方式不同又随机分成联合组和对照组。其中对照组患者口服甘草酸苷制剂，联合组在此基础上联合卡泊三醇搽剂局部治疗。治疗疗程均为12周，每2～4周复诊1次，观察患者治疗效果和局部不良反应等情况。结果：斑秃患者血清25-羟维生素D3水平显著低于健康志愿组(P<0.05)。接受卡泊三醇治疗其临床有效率显著高于未接受卡泊三醇者(P<0.05)。结论：血清25-羟维生素D3水平可能参与斑秃发病机制，卡泊三醇治疗斑秃有效，其疗效在血清25-羟维生素D3水平正常和低下患者中无明显差异。

    [关键词]斑秃;25-羟维生素D3;卡泊三醇;甘草酸苷制剂;维生素D受体

    [中图分类号]R758.71 [文献标志码]A [文章编号]1008-6455(2019)10-0069-03

    Abstract： Objective To investigate the serum level of 25-hydroxyvitamin D3 and the clinical efficacy of topical calcipotriol in the patients with alopecia areata. Methods A total of 92 patients with alopecia areata and 60 healthy controls were enrolled to compare the serum 25-hydroxyvitamin D3 levels in our hospital. The patients with alopecia areata were divided into normal group and lower group according to serum 25-hydroxyvitamin D3 level. They were randomly divided into combined group and control group ......